Dr. WONG PO FUN (Nick Cheung) joins Life Force, an international medical humanitarian organization, to carry out the unfulfilled wish of his deceased girlfriend, HA HIU-TUNG (Gigi Leung). He also sets up Lung Shing Medical Centre to help the poor.
When Fun is working with the organization in Kenya, he meets a young doctor called CHAI PAK-HANG (Raymond Lam), who works at a private hospital named Ling Siu in Hong Kong. Influenced by Fun, Hang joins Lung Shing later. HONG KIU (Sonija Kwok), a nurse at Ling Siu, is impressed by Fun with his principle of putting patients first. However, Fun cannot get over Tung. Meanwhile, Hang meets a volunteer HA HIU-CHING (Leila Tong) when he is in Africa and likes her very much. When they meet at Lung Shing again, Ching hangs back because of the existence of KO SIU-YAU (Sharon Chan), who comes from a wealthy family.
Working with Fun at both Lung Shing and Life Force, Hang learns that apart from giving patients medical treatments, doctors should also help patients to live a meaningful life. However, when Hang and Fun face their own lifetime challenges, they feel weak and helpless.